
Listed by Practice Real Estate Group
Undisclosed Rate
Sienna Plantation Medical Center
Building Details
Property Type Office
Sub Type Medical Office
Tenancy Multiple
Lease Type NNN
Total Building SqFt 32,000
Vacant SqFt 16,000
Spaces
Rent: Call for Pricing
NNN: $10.44 SF
$45 Tenant improvement allowance
Full floor availability for single tenant or multi-tenant options
Customize your medical space with flexible build-out options
Office | 1 space available | 16,000 SqFt
Building description
Looking for premium medical office space Sienna TX? This exceptional 16,000 SF opportunity is strategically located at State Hwy 6 and Sienna Ranch Rd in the thriving Sienna Plantation community. Positioned in the Sienna Plantation Medical Center with MD Anderson as the first-floor tenant, this property offers healthcare providers exceptional visibility and prestigious association. Construction is currently underway with scheduled core and shell delivery in Q4-2025.
Building highlights
- State Hwy 6 and Sienna Ranch Rd, Missouri City, TX 77459
- High visibility and easy access
- 16,000 SF full-floor opportunity on the second floor in shell condition
- Part of a modern 32,000 SF medical building
- New construction with delivery scheduled for Q4-2025
- Flexible build-out options to meet healthcare providers’ specific needs
- Generous $45/SF tenant improvement allowance
- Ample surface parking at 5 spaces per 1,000 SF
- Construction is underway
- Prominent State Hwy 6 and Sienna Ranch Rd intersection with high visibility
- First-floor anchor tenant: MD Anderson Cancer Center
- Surrounded by affluent residential communities in Sienna Plantation
- Near multiple schools including Elkins High School and Sonal Bhuchar Elementary
- Adjacent to established retail including Lifetime Fitness, HEB, and numerous restaurants
- Easy access from multiple residential communities within Sienna
Listing Contacts

Listed by Practice Real Estate Group
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