4053 Market Street, Philadelphia, PA 19104

Premium 2,200 SF Ground-Floor Commercial Space Available for Lease Location: 40th & Market Street, Philadelphia, PA 19104 (University City)

Position your business at the epicenter of Philadelphia’s premier innovation, medical, and academic district. This exceptional ground-floor commercial opportunity offers approximately 2,200 SF of highly visible, flexible space directly on Market Street. Situated at a high-traffic, pedestrian-heavy intersection, the property sits on the ground floor of a vibrant mixed-use building with residential units above, ensuring a built-in, sophisticated daytime and evening customer base.

Unmatched Transit-Oriented Accessibility Logistics and commuting are effortless. The property is located directly adjacent to the SEPTA Market-Frankford Line’s 40th Street Subway Station, seamlessly connecting your business to Center City and West Philadelphia. Multiple trolley and bus lines converge at this intersection, providing unparalleled accessibility for employees, clients, and patients alike.

Flexible CMX-4 Zoning & Ideal Uses Featuring high-density Commercial Mixed-Use zoning (CMX-4), the property permits a wide array of commercial operations by-right. The versatile, wide-open layout is uniquely positioned to accommodate:

• • Medical & Healthcare: Outpatient clinics, physical therapy/rehab centers, dental practices, or wellness facilities looking to tap into the local healthcare ecosystem.
  • Retail & Specialty Food: High-end boutique grocers, specialty markets, cafés, beverage concepts, or service-oriented retail capitalizing on the heavy student and commuter foot traffic.
  • Professional & Tech Space: Corporate offices, educational services, daycare operators, or technology showrooms seeking a prominent storefront presence.

The University City Advantage University City is one of the most dynamic and rapidly growing commercial corridors in the Northeast. This location places your brand minutes away from world-renowned anchors, including the University of Pennsylvania, Drexel University, Penn Medicine, and the Children’s Hospital of Philadelphia (CHOP). Driven by a massive daytime population of students, faculty, healthcare professionals, and researchers, this neighborhood offers an exceptional demographic profile with robust purchasing power.

Don't miss the chance to secure a prominent corporate or retail footprint in Philadelphia’s most sought-after institutional hub.

Lease Terms:

• • Space Available: +/- 2,200 SF (Ground Floor)
  • Base Rent: $7,250 / Month
  • Preferred Term: 5–10 Years
  • Availability: September 1, 2026

For more information or to schedule a private walkthrough, contact the listing agent today.