4040 University Ave, Des Moines, IA 50311

Former US Cellular retail space. 1143 42nd Street is quite literally at Main & Main. Constructed sometime in the early-to-mid 20th century, this character-rich property sits at the corner of 42nd and University Avenue — one of the most recognizable intersections on Des Moines' west side — where the energy of the Drake neighborhood hums around you every single day.

The available suite offers a rare combination: bones that tell a story and infrastructure that means business. Modern electrical, plumbing, and data systems mean you're not trading charm for capability. Ample on-site parking removes the friction that plagues so many urban addresses. And concierge-level property management means that when something needs attention, it gets handled — quietly, professionally, before it becomes your problem.

The space is well-suited for professional office, boutique retail, or medical/wellness uses with appropriate updates. Whatever your business, the address works in your favor.

And then there's the neighborhood. The Drake neighborhood is one of the largest, oldest, and most diverse in Des Moines — home to Drake University, the city's oldest independent art-house movie theater, coffee shops, pubs, great restaurants, century-old churches, mature trees, a fabulous live music and art scene, and incredible people. The Uptown Shopping Center at 42nd and University is anchored by Hy-Vee and draws a diverse mix of businesses and daily foot traffic, making your corner one of the most visible and accessible commercial addresses in the area.

This is a neighborhood where people are looking for walkable areas with unique local businesses to support. It's a community that shows up — for the businesses, the people, and the places that are authentically part of it.

If you're ready to plant your flag somewhere that means something, this is your corner.