

4220 Duncan Ave, St. Louis, MO 63110
Spaces
Available Cafe for Rent
Building description
Ready for Immediate Occupancy | 5,263 SF Interior + 2,126 SF Outdoor Patios
Seize the opportunity to establish your business in one of St. Louis’ most dynamic and thriving innovation hubs. This fully built-out 5,263 square foot restaurant space is available immediately and includes two expansive outdoor patios totaling 2,126 square feet — ideal for high-volume dining, events, and seasonal activation.
Property Highlights:
· Fully built, move-in ready restaurant space
· Total usable area: 7,389 SF (5,263 SF interior + 2,126 SF patio space)
· Located in the Cortex Innovation District, a $1.33B, 200-acre innovation and technology hub
· Surrounded by premier institutions, research centers, and startups
· Centrally located between the historic Central West End and Forest Park Southeast neighborhoods
· Easy access to nationally ranked medical centers and universities
· Near major cultural and recreational destinations, including Forest Park, Grand Center, and Missouri Botanical Garden
Position your concept at the epicenter of innovation and connectivity in St. Louis — perfect for operators seeking a high-energy, high-growth location.
Building highlights
Ready for Immediate Occupancy | 5,263 SF Interior + 2,126 SF Outdoor Patios
Seize the opportunity to establish your business in one of St. Louis’ most dynamic and thriving innovation hubs. This fully built-out 5,263 square foot restaurant space is available immediately and includes two expansive outdoor patios totaling 2,126 square feet — ideal for high-volume dining, events, and seasonal activation.
Property Highlights:
· Fully built, move-in ready restaurant space
· Total usable area: 7,389 SF (5,263 SF interior + 2,126 SF patio space)
· Located in the Cortex Innovation District, a $1.33B, 200-acre innovation and technology hub
· Surrounded by premier institutions, research centers, and startups
· Centrally located between the historic Central West End and Forest Park Southeast neighborhoods
· Easy access to nationally ranked medical centers and universities
· Near major cultural and recreational destinations, including Forest Park, Grand Center, and Missouri Botanical Garden
Position your concept at the epicenter of innovation and connectivity in St. Louis — perfect for operators seeking a high-energy, high-growth location.
Listing Contacts


Map
Property History
Similar Properties
Is there information that looks off?



















