St Matthews Rd, Orangeburg, SC 29115 For Sale

This ±102‑acre mixed-use development site in Orangeburg, South Carolina, offers a versatile opportunity for residential, retail and commercial development within one of the market’s active corridors. Featuring strong frontage on Hwy 601 (St. Matthews Road) and on‑site utilities, the proposed site plan includes residential acreage, big‑box retail, outparcels, office/neighborhood commercial parcels and a convenience store pad. Its proximity to major employers, educational institutions and expanding industrial operations enhances long-term demand drivers, making it an attractive investment for developers seeking opportunities in a growing regional market.

The St. Matthews Road corridor in Orangeburg, SC, presents a highly attractive market for retail property buyers thanks to its strategic location and robust commercial activity. The area benefits from easy access to I‑26 Exit 145 (±55,200 VPD), nearby Orangeburg-Calhoun Technical College and MUSC Health, creating a built-in customer base. Currently zoned as General Commercial, this property is located within a growing business corridor supported by established retail, healthcare, and financial services, making it a strong development opportunity in Orangeburg.