110 S Main St, Wichita, KS 67202

110 S. Main presents a rare opportunity to acquire a 10-story, ±114,770 SF building in the heart of Downtown Wichita, well-suited for office, mixed-use, or residential conversion.

The property sits one block from the new Wichita Biomedical Campus—a more than $200 million project expected to bring approximately 3,000 students and faculty downtown, driving demand for housing, office, and amenities.

Surrounded by Wichita’s most active destinations, the building is within walking distance of Intrust Bank Arena, Equity Bank Park (Riverfront Stadium), Old Town, and the Delano District—offering a strong mix of dining, entertainment, and everyday conveniences. The nearby Arkansas River paths, Naftzger Park, and surrounding public spaces add to the area’s walkability and appeal.

Downtown Wichita continues to gain momentum with ongoing redevelopment, new residential units, and adaptive reuse projects bringing new life to historic buildings. Combined with quick access to Kellogg/U.S. 54, the location offers both connectivity and a growing built-in user base.

Parking is a key advantage, with 14 on-site spaces and multiple nearby garages, including the 434-space Market & William Garage and 400-space Intrust Garage, as well as additional metered parking at Century II, providing ample options for tenants, residents, and visitors.

Overall, 110 S. Main is positioned to benefit from continued downtown investment, increasing density, and strong surrounding amenities making it a compelling opportunity in Wichita’s urban core.