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Retail 

South Carolina Medical Office Spaces for Lease

2,783 spaces
Pictures of Retail property located at 253 Forum Dr, Columbia, SC 29229 for lease - image #1
Undisclosed Rate
253 Forum Dr
Retail • 1 space available • 2,644 SqFt - 10,145 SqFt

253 Forum Dr Columbia, SC 29229

Pictures of Retail, Office, Industrial property located at 2114 Chesnee Hwy, Spartanburg, SC 29303 for lease - image #1
$12/SF/YR
Multi Tenant Flex Building
Retail' Flex • 2 spaces available • 1,000 SqFt - 2,000 SqFt

2114 Chesnee Hwy Spartanburg, SC 29303

Pictures of Office property located at 90 Brighton Hill Road, Columbia, SC 29205 for lease - image #1
$14/SF/YR
90 Brighton Hill Road
Office • Single tenant • 6,564 SqFt

90 Brighton Hill Road Columbia, SC 29205

Pictures of Retail property located at 5188 Calhoun Memorial Hwy, Easley, SC 29640 for lease - image #1
Undisclosed Rate
5188 Calhoun Memorial Hwy
1,302 SF Building on 0.51 Acres

5188 Calhoun Memorial Hwy Easley, SC 29640

Pictures of Retail, Restaurant property located at 120 Forum Dr, Columbia, SC 29229 for lease - image #1
Undisclosed Rate
Village at Sandhill
Retail • 2 spaces available • 1,191 SqFt - 3,774 SqFt

120 Forum Dr Columbia, SC 29229

Pictures of Retail, Office property located at 6932 Calhoun Memorial Hwy, Easley, SC 29640 for lease - image #1
$15/SF/YR
6932 Calhoun Memorial Hwy-Retail
Retail • 1 space available • 1,200 SqFt

6932 Calhoun Memorial Hwy Easley, SC 29640

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Pictures of Retail, Industrial property located at 1436 Meeting St, Charleston, SC 29405 for lease - image #1
Undisclosed Rate
Flex Retail Space
Flex Retail Space for Lease

1436 Meeting St Charleston, SC 29405

Pictures of Retail property located at 229 Bush River Rd, Columbia, SC 29210 for lease - image #1
Undisclosed Rate
Former Chick-fil-A
Former Chick-fil-A • 3,747 SF

229 Bush River Rd Columbia, SC 29210

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Pictures of Retail property located at 630 Bypass 25 NE, Greenwood, SC 29646 for lease - image #1
Undisclosed Rate
630 Bypass 25 NE
Retail • Single tenant • 3,321 SqFt

630 Bypass 25 NE Greenwood, SC 29646

Pictures of Retail, Office, Industrial property located at 380 Whitney Rd, Spartanburg, SC 29303 for lease - image #1
$6/SF/YR
380 Whitney Rd
Retail • Single tenant • 22,086 SqFt

380 Whitney Rd Spartanburg, SC 29303

Pictures of Retail, Restaurant property located at 123 Spartanburg Hwy, Lyman, SC 29365 for lease - image #1
Undisclosed Rate
123 Spartanburg Hwy
Retail • 1 space available • 1,000 SqFt - 9,000 SqFt

123 Spartanburg Hwy Lyman, SC 29365

Pictures of Retail property located at 739 Galleria Blvd, Rock Hill, SC 29730 for lease - image #1
Undisclosed Rate
Parkway Plaza
Retail • 1 space available • 1,200 SqFt - 3,900 SqFt

739 Galleria Blvd Rock Hill, SC 29730

Pictures of Retail property located at 2230 Daisy Ln, Indian Land, SC 29707 for lease - image #1
Undisclosed Rate
The Exchange
Retail • Single tenant • 800 SqFt - 6,500 SqFt

2230 Daisy Ln Indian Land, SC 29707

Pictures of Retail, Office property located at 413 Main St, New Ellenton, SC 29809 for lease - image #1
$18.83/SF/YR
Unit 1 Office/Retail
Retail/Office Space in New Ellenton

413 Main St New Ellenton, SC 29809

Pictures of Retail property located at 1214 Saint Matthews Road, Ste 308, Orangeburg, SC 29115 for lease - image #1
$10/SF/YR
Orangeburg Mall for Lease
Retail • Single tenant • 6,000 SqFt

1214 Saint Matthews Road, Ste 308 Orangeburg, SC 29115

Pictures of Retail property located at 1214 Saint Matthews Road, Ste 321, Orangeburg, SC 29115 for lease - image #1
$10/SF/YR
Orangeburg Mall for Lease
Retail • Single tenant • 4,550 SqFt

1214 Saint Matthews Road, Ste 321 Orangeburg, SC 29115

Pictures of Retail, Office property located at 2601 E Main St, Spartanburg, SC 29307 for lease - image #1
$14/SF/YR
2601 E. Main Street
Retail • Single tenant • 700 SqFt

2601 E Main St Spartanburg, SC 29307

Pictures of Retail, Land property located at 122 Milestone Way, Greenville, SC 29615 for lease - image #1
Undisclosed Rate
Pintail - 122 Milestone Way
Retail • Single tenant • 6,415 SqFt

122 Milestone Way Greenville, SC 29615

Pictures of Office property located at 5187 Horry Dr, Murrells Inlet, SC 29576 for lease - image #1
$22/SF/YR
5187 Horry Drive
Office • 1 space available • 1,000 SqFt

5187 Horry Dr Murrells Inlet, SC 29576

Pictures of Retail, Office, Restaurant property located at 1421 Laurens Rd, Greenville, SC 29607 for lease - image #1
$25/SF/YR
1421 Laurens Road - Renovations Coming 2026
Retail/Office • RENOVATIONS PLANNED TO BE COMPLETE SUMMER 2026

1421 Laurens Rd Greenville, SC 29607

Pictures of Retail property located at 395 Corner Square Plaza, Moncks Corner, SC 29461 for lease - image #1
$21,273 - $25,528/SF/YR
395 Corner Square Plaza
Retail • Single tenant • 851 SqFt

395 Corner Square Plaza Moncks Corner, SC 29461

Pictures of Office property located at 7659 Garners Ferry Rd, Columbia, SC 29209 for lease - image #1
Undisclosed Rate
7659 Garners Ferry Road
Medical office space for sale or lease

7659 Garners Ferry Rd Columbia, SC 29209

Pictures of Retail, Office property located at 41 Simons St, Charleston, SC 29403 for lease - image #1
$8.67/SF/MO
41 Simons Street - Suite with Storefront
Retail • Single tenant • 368 SqFt

41 Simons St Charleston, SC 29403

Pictures of Retail, Restaurant property located at 119 E POINSETT ST, GREER, SC 29651-3405 for lease - image #1
video
Undisclosed Rate
119 E POINSETT ST GREER SC 29651-3405
Retail Space for Lease in Downtown Greer

119 E POINSETT ST GREER, SC 29651-3405

Pictures of Restaurant, Retail property located at 83 Mary Street # 300, Charleston, SC 29403 for lease - image #1
$35/SF/YR
83 Mary Street # 300
Restaurant • Single tenant • 1,857 SqFt - 8,317 SqFt

83 Mary Street # 300 Charleston, SC 29403

Pictures of Retail property located at 3415 Clemson Blvd, Anderson, SC 29621 for lease - image #1
Undisclosed Rate
3415 Clemson Blvd
Retail • 2 spaces available • 10,000 SqFt

3415 Clemson Blvd Anderson, SC 29621

Pictures of Retail property located at 1291 Folly Road # 3b, Charleston, SC 29412 for lease - image #1
Undisclosed Rate
Island Plaza Shopping Center
Retail • Single tenant • 1,800 SqFt

1291 Folly Road # 3b Charleston, SC 29412

Pictures of Office property located at 2102 Cromley Cir, Myrtle Beach, SC 29577 for lease - image #1
$18.55/SF/YR
Cromley Office Building
Office • Single tenant • 2,400 SqFt

2102 Cromley Cir Myrtle Beach, SC 29577

Pictures of Retail, Land property located at 11859 S.C. Highway 707, Murrells Inlet, SC 29576 for lease - image #1
Undisclosed Rate
Murrells Inlet
Retail • 2 spaces available • 2,400 SqFt - 3,050 SqFt

11859 S.C. Highway 707 Murrells Inlet, SC 29576

Pictures of Retail property located at 179 Church Street #E, Charleston, SC 29401 for lease - image #1
$87.55/SF/YR
179 Church Street #E
Retail • Single tenant • 1,105 SqFt

179 Church Street #E Charleston, SC 29401

Pictures of Retail, Industrial, Office property located at 5640 Rivers Avenue # C, North Charleston, SC 29406 for lease - image #1
$19/SF/YR
5640 Rivers Avenue # C
Retail • Single tenant • 4,336 SqFt - 10,926 SqFt

5640 Rivers Avenue # C North Charleston, SC 29406

Pictures of Retail property located at 4998 Carolina Forest Blvd, Myrtle Beach, SC 29579 for lease - image #1
$34 - $36/SF/YR
4998 Carolina Forest Blvd Proposed Strip Center
Retail • 3 spaces available • 1,567 SqFt - 7,972 SqFt

4998 Carolina Forest Blvd Myrtle Beach, SC 29579

Pictures of Retail property located at 8510 Rivers Avenue # J #H-J, Charleston, SC 29406 for lease - image #1
$17/SF/YR
8510 Rivers Avenue # J #H-J
Retail • Single tenant • 1,600 SqFt - 4,800 SqFt

8510 Rivers Avenue # J #H-J Charleston, SC 29406

Pictures of Retail property located at 1711 Old Trolley Road, Summerville, SC 29485 for lease - image #1
$30/SF/YR
1711 Old Trolley Road
Retail • Single tenant • 1,250 SqFt - 2,500 SqFt

1711 Old Trolley Road Summerville, SC 29485

Pictures of Retail property located at 1150 S Fourth St, Hartsville, SC 29550 for lease - image #1
Undisclosed Rate
Hartsville Crossing
Retail • 3 spaces available • 1,200 SqFt - 6,000 SqFt

1150 S Fourth St Hartsville, SC 29550

Pictures of Retail, Restaurant property located at 4100 Pelham Road, Greenville, SC 29615 for lease - image #1
$1/SF/YR
4100 Pelham Road
Retail • Single tenant • 2,500 SqFt - 5,180 SqFt

4100 Pelham Road Greenville, SC 29615

Pictures of Retail property located at Carolina Park Boulevard Bldg 2 #Restaurant Bldg 2, Unit 2, Mount Pleasant, SC 29466 for lease - image #1
$48/SF/YR
Carolina Park Boulevard Bldg 2 #Restaurant Bldg 2, Unit 2
Retail • Single tenant • 2,550 SqFt - 4,050 SqFt

Carolina Park Boulevard Bldg 2 #Restaurant Bldg 2, Unit 2 Mount Pleasant, SC 29466

Pictures of Retail property located at Carolina Park Boulevard Bldg 1 #Restaurant Bldg 2, Unit 1, Mount Pleasant, SC 29466 for lease - image #1
$48/SF/YR
Carolina Park Boulevard Bldg 1 #Restaurant Bldg 2, Unit 1
Retail • Single tenant • 1,200 SqFt - 4,200 SqFt

Carolina Park Boulevard Bldg 1 #Restaurant Bldg 2, Unit 1 Mount Pleasant, SC 29466

Pictures of Special Purpose, Retail, Office property located at Carolina Park Boulevard # 5 #Building B, Unit 5, Mount Pleasant, SC 29466 for lease - image #1
$36/SF/YR
Carolina Park Boulevard # 5 #Building B, Unit 5
Special Purpose • Single tenant • 1,400 SqFt - 7,200 SqFt

Carolina Park Boulevard # 5 #Building B, Unit 5 Mount Pleasant, SC 29466

Pictures of Office property located at 3400 Salterbeck Street # 100c, Mount Pleasant, SC 29466 for lease - image #1
$23.50/SF/YR
Salterbeck Commercial Village
Office • Single tenant • 1,523 SqFt

3400 Salterbeck Street # 100c Mount Pleasant, SC 29466

Pictures of Retail, Restaurant property located at 439 William Hilton Pkwy, Hilton Head Island, SC 29926 for lease - image #1
Undisclosed Rate
Former IHOP
Retail • Single tenant • 5,172 SqFt

439 William Hilton Pkwy Hilton Head Island, SC 29926

Pictures of Office, Retail property located at 517 King Street Street # 4, Charleston, SC 29403 for lease - image #1
$30/SF/YR
517 King Street Street # 4
Office • Single tenant • 4,334 SqFt

517 King Street Street # 4 Charleston, SC 29403

Pictures of Retail, Office, Special Purpose property located at 5110 Fairfield Rd, Columbia, SC 29203 for lease - image #1
virtual tour
$11/SF/YR
Food Lion–Anchored Retail Center | Fairfield Rd
Food Lion–Anchored Retail & Medical Space • 3,600–14,208 SF

5110 Fairfield Rd Columbia, SC 29203

Pictures of Retail property located at 2137 Savannah Hwy, Charleston, SC 29414 for lease - image #1
$24/SF/YR
2137 Savannah Highway
Retail • Single tenant • 23,983 SqFt

2137 Savannah Hwy Charleston, SC 29414

Pictures of Retail property located at 630 Skylark Drive # U, Charleston, SC 29407 for lease - image #1
$25/SF/YR
630 Skylark Drive # U
Retail • 1 space available • 1,580 SqFt - 6,400 SqFt

630 Skylark Drive # U Charleston, SC 29407

Pictures of Office property located at 9403 Highway 78 # 4 #Floors 1-4, Ladson, SC 29456 for lease - image #1
$30 - $35/SF/YR
Ingleside Medical Center
Office • Single tenant • 5,000 SqFt - 42,000 SqFt

9403 Highway 78 # 4 #Floors 1-4 Ladson, SC 29456

Pictures of Retail property located at 2507 Whitehall Ave, Anderson, SC 29621 for lease - image #1
$11/SF/YR
2507 Whitehall Ave
Retail • Single tenant • 1,975 SqFt

2507 Whitehall Ave Anderson, SC 29621

Pictures of Retail, Industrial property located at 1106 Rutherfordton Hwy 221, Chesnee, SC 29323 for lease - image #1
Undisclosed Rate
1106 Rutherfordton Hwy 221
Retail • Single tenant • 5,000 SqFt

1106 Rutherfordton Hwy 221 Chesnee, SC 29323

Pictures of Retail property located at 172 E MAIN ST, SPARTANBURG, SC 29306-5181 for lease - image #1
$32/SF/YR
172 E MAIN ST SPARTANBURG SC 29306-5181

172 E MAIN ST SPARTANBURG, SC 29306-5181

Pictures of Retail, Industrial property located at 1208 Union St, Spartanburg, SC 29302 for lease - image #1
$12/SF/YR
1208 Union St
Retail • 1 space available • 4,000 SqFt

1208 Union St Spartanburg, SC 29302

Pictures of Retail, Office property located at 2509 Stone Station Rd, Roebuck, SC 29376 for lease - image #1
$20/SF/YR
Lease Space, Retail, or Office Use
2509 Stone Station Rd, Roebuck, SC 29376

2509 Stone Station Rd Roebuck, SC 29376

Pictures of Retail, Special Purpose property located at 1050 Fording Island Road, Bluffton, SC 29910 for lease - image #1
$28/SF/YR
1050 Fording Island Road

1050 Fording Island Road Bluffton, SC 29910

Pictures of Office, Industrial, Retail property located at 320 E Main Street Unit B, Moncks Corner, SC 29461 for lease - image #1
$2,300/SF/YR
320 E Main Street Unit B
Office • Single tenant • 1,400 SqFt

320 E Main Street Unit B Moncks Corner, SC 29461

Pictures of Office, Special Purpose property located at 100 Corporate Boulevard, West Columbia, SC 29169 for lease - image #1
$15.55/SF/YR
100 Corporate Boulevard
Move-In Ready ±17,800 SF Office Building with Showroom

100 Corporate Boulevard West Columbia, SC 29169

Pictures of Retail property located at 1724 Old York Road, York, SC 29745 for lease - image #1
$18/SF/YR
1724 Old York Road
Retail • Single tenant

1724 Old York Road York, SC 29745

Pictures of Retail property located at 348 Broad St, Sumter, SC 29150 for lease - image #1
Undisclosed Rate
348 Broad St
Retail • 1 space available • 3,000 SqFt

348 Broad St Sumter, SC 29150

Pictures of Retail, Office property located at 200 N Main St, Greenville, SC 29601 for lease - image #1
$24.50/SF/YR
Office / Retail - Downtown Greenville
Retail • 1 space available • 3,481 SqFt

200 N Main St Greenville, SC 29601

Pictures of Retail, Office, Restaurant property located at 3500 Belle Terre Blvd, Myrtle Beach, SC 29579 for lease - image #1
$33 - $35/SF/YR
Forestbrook Commons
Retail • 1 space available • 1,200 SqFt - 12,000 SqFt

3500 Belle Terre Blvd Myrtle Beach, SC 29579

Pictures of Retail property located at 854 Jason Blvd, Myrtle Beach, SC 29577 for lease - image #1
$22/SF/YR
854 Jason Blvd
±1,983 SF Retail / Showroom Space with Drive-In Door • Myrtle Beach, SC

854 Jason Blvd Myrtle Beach, SC 29577

Pictures of Retail, Office property located at 200 Georgia Ave, North Augusta, SC 29841 for lease - image #1
$24 - $30/SF/YR
Beacon Bluff
Office • 3 spaces available • 1,352 SqFt - 10,000 SqFt

200 Georgia Ave North Augusta, SC 29841

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