www.crexi.com - The Commercial Real Estate Exchange
For Lease
Retail 

South Carolina Medical Office Spaces for Lease

2,783 spaces
Pictures of Retail property located at 942 S Main St, Greenville, SC 29601 for lease - image #1
$30.95/SF/YR
2nd Gen Restaurant Main St.
Retail • Single tenant • 3,370 SqFt

942 S Main St Greenville, SC 29601

Pictures of Retail property located at 207 W Butler Road, Mauldin, SC 29662 for lease - image #1
$17/SF/YR
Butler Square
Retail • Single tenant • 14,800 SqFt

207 W Butler Road Mauldin, SC 29662

Pictures of Retail property located at 2001 Woodruff Rd, Greenville, SC 29607 for lease - image #1
Undisclosed Rate
Former Pizza Inn - Woodruff Road
Retail • Single tenant • 1 acre

2001 Woodruff Rd Greenville, SC 29607

Pictures of Retail property located at 787 East Butler Road, Mauldin, SC 29662 for lease - image #1
$25/SF/YR
Crescent Wood Village
787 East Butler Road, Mauldin, SC 29662

787 East Butler Road Mauldin, SC 29662

Pictures of Retail, Office property located at 2247 Augusta St, Greenville, SC 29605 for lease - image #1
Undisclosed Rate
2247 Augusta St
Retail • Single tenant

2247 Augusta St Greenville, SC 29605

Pictures of Retail property located at 825 Bethel St, Clover, SC 29710 for lease - image #1
Undisclosed Rate
Clover Plaza
Retail • 1 space available • 1 SqFt - 29,000 SqFt

825 Bethel St Clover, SC 29710

INTELLIGENCE
Instantly evaluate properties and markets with confidence.
Analyze data, market trends, sales comps, demographics, and more.
Learn More
Pictures of Retail, Office property located at 1320 44th Avenue North, Myrtle Beach, SC 29577 for lease - image #1
$27/SF/YR
OLA PLAZA

1320 44th Avenue North Myrtle Beach, SC 29577

Pictures of Retail, Office property located at 4390 Spa Dr, Little River, SC 29566 for lease - image #1
Undisclosed Rate
Spa Drive Plaza
Retail

4390 Spa Dr Little River, SC 29566

See New Listings First!
Save your filters and get alerts when new properties hit the market.
Save My Search
Pictures of Retail, Land property located at 893 Edgefield Rd, North Augusta, SC 29841 for lease - image #1
video
Undisclosed Rate
North Augusta | Exit 5 Retail 34K VPD | 0.6 Miles to I-20
Retail • 2 spaces available • 1 acre - 1 acre

893 Edgefield Rd North Augusta, SC 29841

Pictures of Land, Retail property located at 247 W Church St, Batesburg-Leesville, SC 29006 for lease - image #1
video
Undisclosed Rate
Batesburg-Leesville Retail Land | 1.86 Acres
Batesburg-Leesville Retail Land • 1.86 Acres

247 W Church St Batesburg-Leesville, SC 29006

Pictures of Retail, Office property located at 505 SE Main St, Simpsonville, SC 29681 for lease - image #1
Undisclosed Rate
505 SE Main St
Retail • 1 space available • 1,500 SqFt

505 SE Main St Simpsonville, SC 29681

Pictures of Retail property located at 1622 Woodruff Rd, Greenville, SC 29607 for lease - image #1
Undisclosed Rate
1622-1624 Woodruff Rd
Retail • 1,080 sq. ft.

1622 Woodruff Rd Greenville, SC 29607

Pictures of Office property located at 1650 Skylyn Dr, Spartanburg, SC 29307 for lease - image #1
Undisclosed Rate
Hugh R. Black Pavilion
On campus medical office space available

1650 Skylyn Dr Spartanburg, SC 29307

Pictures of Office property located at 4225 Carolina Exchange Drive, Myrtle Beach, SC 29579 for lease - image #1
$18/SF/YR
CF Prof Building Medical Office - Suite B
Office • 1 space available • 1,150 SqFt

4225 Carolina Exchange Drive Myrtle Beach, SC 29579

Pictures of Retail, Office property located at 528 US-17 BUS, Myrtle Beach, SC 29577 for lease - image #1
$20/SF/YR
Gator Hole Plaza
Retail/Office • 1 space available • 2,939 SF

528 US-17 BUS Myrtle Beach, SC 29577

Pictures of Retail property located at 200 Hwy 17 N, North Myrtle Beach, SC 29582 for lease - image #1
$25/SF/YR
Surfwood Plaza Shopping Center
For Lease • 2,800 sq. ft. - 13,626 sq. ft.

200 Hwy 17 N North Myrtle Beach, SC 29582

Pictures of Retail, Office property located at 320 Broad St, Charleston, SC 29401 for lease - image #1
$110.09 - $196.22/SF/YR
Ashley Artisan Suites at The Jasper
Start Your Business at Ashley Artisan Suites in Downtown Charleston

320 Broad St Charleston, SC 29401

Pictures of Retail, Office, Restaurant property located at 5529 Arden Mill Dr, Fort Mill, SC 29715 for lease - image #1
$34.75/SF/YR
Arden Mill Square
Retail • One space (end-cap) still available 2,076 SF

5529 Arden Mill Dr Fort Mill, SC 29715

Pictures of Office property located at 100 Exchange St, Hilton Head Island, SC 29926 for lease - image #1
$22.50/SF/YR
North End Office or Medical Space for Lease
Office • 1 space available • 1,726 SqFt

100 Exchange St Hilton Head Island, SC 29926

Pictures of Retail, Land property located at 141 Dorman Centre Drive, Spartanburg, SC 29301 for lease - image #1
Undisclosed Rate
Dorman Centre
Retail • 1 space available • 1 acre

141 Dorman Centre Drive Spartanburg, SC 29301

Pictures of Retail property located at 201 Harbison Blvd, Columbia, SC 29212 for lease - image #1
$16.50 - $28/SF/YR
Harbison Crossing
Retail • 2 spaces available • 1,227 SqFt - 1,350 SqFt

201 Harbison Blvd Columbia, SC 29212

Pictures of Retail property located at Foundation Street, Charleston, SC 29492 for lease - image #1
$35/SF/YR
Foundation Street
Retail • 1 space available • 1,600 SqFt

Foundation Street Charleston, SC 29492

Pictures of Retail property located at 1100 Dutch Fork Rd, Irmo, SC 29063 for lease - image #1
Undisclosed Rate
Dutch Fork Crossing
Retail

1100 Dutch Fork Rd Irmo, SC 29063

Pictures of Retail property located at 101 Edgewood Dr, North Augusta, SC 29841 for lease - image #1
Undisclosed Rate
Edgewood Square
Retail • 4 spaces available • 1,000 SqFt - 50,285 SqFt

101 Edgewood Dr North Augusta, SC 29841

Pictures of Retail property located at 161 S Aiken Ln, Aiken, SC 29803 for lease - image #1
$25/SF/YR
Shoppes at Whiskey
Retail • 1 space available • 1,200 SqFt

161 S Aiken Ln Aiken, SC 29803

Pictures of Retail, Land property located at 2081 E Main St, Spartanburg, SC 29307 for lease - image #1
Undisclosed Rate
East Main Centre
Retail • 1 space available • 1,570 SqFt - 25,396 SqFt

2081 E Main St Spartanburg, SC 29307

Pictures of Office property located at 500 Taylor St, Columbia, SC 29201 for lease - image #1
video
$23.25 - $25/SF/YR
Vista Business Center at 500 Taylor
Premier Class A Office Space with Excellent Visibility & Accessibility

500 Taylor St Columbia, SC 29201

Pictures of Retail, Office property located at 1201 Main St, Columbia, SC 29201 for lease - image #1
$21.50 - $26.50/SF/YR
Capitol Center
Prominent Class A Office Space in the Heart of Downtown Columbia

1201 Main St Columbia, SC 29201

Pictures of Retail, Office property located at 810 Dutch Square Blvd, Columbia, SC 29210 for lease - image #1
$12.50 - $14.50/SF/YR
The Dutch Center
Retail • 1 space available • 200 SqFt - 6,912 SqFt

810 Dutch Square Blvd Columbia, SC 29210

Pictures of Retail property located at 1944 Whiskey Rd, Aiken, SC 29803 for lease - image #1
$22/SF/YR
1944 Whiskey Road-Suite B
Retail • 1 space available • 2,137 SqFt

1944 Whiskey Rd Aiken, SC 29803

Pictures of Retail, Office property located at 7358-7372 Two Notch Rd, Columbia, SC 29223 for lease - image #1
$14/SF/YR
Tillman’s Plaza
Retail • 2 spaces available • 1,215 SqFt - 2,259 SqFt

7358-7372 Two Notch Rd Columbia, SC 29223

Pictures of Retail property located at 7467 St Andrews Rd, Irmo, SC 29063 for lease - image #1
Undisclosed Rate
7467 St Andrews Rd
Retail • 3 spaces available • 1,750 sq. ft. - 2,558 sq. ft.

7467 St Andrews Rd Irmo, SC 29063

Pictures of Office property located at 2670 Mills Park Dr, Rock Hill, SC 29732 for lease - image #1
Undisclosed Rate
2670 Mills Park Drive
Office • 2 spaces available • 3,500 SqFt - 14,837 SqFt

2670 Mills Park Dr Rock Hill, SC 29732

Pictures of Office, Retail, Restaurant property located at 900 E Main St, Easley, SC 29640 for lease - image #1
$6 - $15/SF/YR
Renovated Retail/Office Spaces for Lease.
+110,000 SF of renovated retail/office space

900 E Main St Easley, SC 29640

Pictures of Retail property located at 505 S Pearl St, Pageland, SC 29728 for lease - image #1
$5/SF/YR
505 S. Pearl St
Retail • 1 space available • 16,500 SqFt

505 S Pearl St Pageland, SC 29728

Pictures of Retail property located at 1616 N Main St, Abbeville, SC 29620 for lease - image #1
$6.95/SF/YR
1616 N. Main St
Retail • 2 spaces available • 1,375 SqFt - 1,875 SqFt

1616 N Main St Abbeville, SC 29620

Pictures of Retail property located at 168 Wall St, Camden, SC 29020 for lease - image #1
$23/SF/YR
Wall Street Commons
Retail • 3 spaces available • 1,278 SqFt - 8,500 SqFt

168 Wall St Camden, SC 29020

Pictures of Retail property located at 221 Robertson Boulevard, Walterboro, SC 29488 for lease - image #1
$6/SF/YR
221 Robertson Boulevard
Retail • 1 space available • 6,000 SqFt

221 Robertson Boulevard Walterboro, SC 29488

Pictures of Retail property located at 1618 Woodruff Rd, Greenville, SC 29607 for lease - image #1
$30/SF/YR
Woodruff Square
Retail Space on Woodruff Rd • 1,450 sq. ft.

1618 Woodruff Rd Greenville, SC 29607

Pictures of Retail, Office property located at 818 Tom Hall St, Fort Mill, SC 29715 for lease - image #1
virtual tour
$29/SF/YR
818 Tom Hall Plaza
Retail • 1 space available • 800 SqFt

818 Tom Hall St Fort Mill, SC 29715

Pictures of Retail property located at 2114 Clemson Road, Columbia, SC 29229 for lease - image #1
Undisclosed Rate
2114 Clemson Road
Retail • 1 space available • 1,535 SqFt

2114 Clemson Road Columbia, SC 29229

Pictures of Retail property located at 355 Faison Road, Mount Pleasant, SC 29466 for lease - image #1
$40/SF/YR
355 Faison Road
Retail • Single tenant • 4,800 SqFt

355 Faison Road Mount Pleasant, SC 29466

Pictures of Office property located at 422 Drive In Lane, Moncks Corner, SC 29461 for lease - image #1
$22 - $25/SF/YR
422 Drive In Lane
Office • Single tenant • 7,490 SqFt

422 Drive In Lane Moncks Corner, SC 29461

Pictures of Retail, Office, Special Purpose property located at 114 E Gay St, Lancaster, SC 29720 for lease - image #1
video
Undisclosed Rate
Retail /Office - Downtown Lancaster, SC
Exciting Opportunity in Downtown Lancaster

114 E Gay St Lancaster, SC 29720

Pictures of Retail, Office property located at 111 Clebourne St, Fort Mill, SC 29715 for lease - image #1
$23 - $27/SF/YR
Clebourne Building: Office, Retail, Restaurant Spaces
Retail • 3 spaces available • 1,508 SqFt - 1,966 SqFt

111 Clebourne St Fort Mill, SC 29715

Pictures of Retail property located at 1808 Asheville Hwy, Spartanburg, SC 29303 for lease - image #1
Undisclosed Rate
1808 Asheville Hwy
Retail • 1 space available • 1 acre

1808 Asheville Hwy Spartanburg, SC 29303

Pictures of Retail, Land property located at 500 2nd Loop Rd, Florence, SC 29505 for lease - image #1
Undisclosed Rate
Langston on the Loop Outparcel
2nd Loop Road • Ground Lease or BTS • Florence, SC

500 2nd Loop Rd Florence, SC 29505

Pictures of Retail property located at 1011 Broad St, Sumter, SC 29150 for lease - image #1
Undisclosed Rate
Sumter Square
Retail • 1 space available • 3,450 SqFt - 6,350 SqFt

1011 Broad St Sumter, SC 29150

Pictures of Retail, Office property located at 111 Caldwell St, Rock Hill, SC 29730 for lease - image #1
$24/SF/YR
111 Caldwell Street
Retail • 1 space available • 1,488 SqFt

111 Caldwell St Rock Hill, SC 29730

Pictures of Retail property located at 644 N Main St, Greenville, SC 29601 for lease - image #1
Undisclosed Rate
644 North Main Street
Retail Space for Lease • Stone Avenue

644 N Main St Greenville, SC 29601

Pictures of Retail, Restaurant property located at 8636 Dorchester Road, North Charleston, SC 29420 for lease - image #1
virtual tour
$33.50/SF/YR
8636 Dorchester Road
Retail • 1 space available • 2,750 SqFt

8636 Dorchester Road North Charleston, SC 29420

Pictures of Retail property located at 300 Union St, Spartanburg, SC 29306 for lease - image #1
$16.50/SF/YR
300 Union Street
Retail • 1 space available • 1,587 SqFt

300 Union St Spartanburg, SC 29306

Pictures of Retail, Office property located at 1417 Stuart Engals Blvd, Mt Pleasant, SC 29464 for lease - image #1
$30/SF/YR
1417 Stuart Engals Blvd
Medical/Office for Lease - 3,130 SF

1417 Stuart Engals Blvd Mt Pleasant, SC 29464

Pictures of Retail, Land property located at 2875 Cherry Rd, Rock Hill, SC 29730 for lease - image #1
$135,000 - $200,000/Acre/YR
Cherry Road Rock Hill, SC Parcels Available
Retail • Single tenant • 1 acre - 2 acre

2875 Cherry Rd Rock Hill, SC 29730

Pictures of Retail, Office property located at 109 W Antrim Dr, Greenville, SC 29607 for lease - image #1
virtual tour
$18/SF/YR
109-115 W. Antrim Dr.
Retail • 1 space available • 1,000 SqFt

109 W Antrim Dr Greenville, SC 29607

Pictures of Retail, Office, Restaurant property located at 2801 Wade Hampton Boulevard, Taylors, SC 29687 for lease - image #1
Undisclosed Rate
Hampton Village
Retail • 1 space available • 1,600 SqFt

2801 Wade Hampton Boulevard Taylors, SC 29687

Pictures of Office property located at 5 Hampton Lake Drive, Bluffton, SC 29910 for lease - image #1
$40/SF/YR
Offices at Hampton Lake
Luxury Office Building For Lease • 5 Hampton Lake • Bluffton SC

5 Hampton Lake Drive Bluffton, SC 29910

Pictures of Office property located at 4225 Carolina Exchange Dr, Myrtle Beach, SC 29579 for lease - image #1
$18/SF/YR
Carolina Forest Professional Office
Office • Single tenant • 1,150 SqFt

4225 Carolina Exchange Dr Myrtle Beach, SC 29579

Pictures of Retail property located at 327 Killian Rd, Columbia, SC 29203 for lease - image #1
$22/SF/YR
331 Killian Road
Retail • 2 spaces available • 1,600 SqFt - 2,080 SqFt

327 Killian Rd Columbia, SC 29203

Pictures of Retail property located at 4500 Ladson Road, Summerville, SC 29485 for lease - image #1
Undisclosed Rate
Ladson Oakbrook Shopping Center
Retail • 3 spaces available • 1 SqFt - 3,000 SqFt

4500 Ladson Road Summerville, SC 29485

For assistance, reach out to our support team at [email protected] or call 888.273.0423 . For press inquiries, contact [email protected]
Equal Housing Opportunity
5510 Lincoln Blvd #400, Los Angeles, CA 90094Commercial Real Estate Exchange, Inc.Crexi Technologies, LLCCXTechnology, LLC
© 2026 Commercial Real Estate Exchange, Inc. All Rights Reserved. DRE #02086591