www.crexi.com - The Commercial Real Estate Exchange
For Lease
Office 

South Carolina Office Spaces for Lease

2,657 spaces
Pictures of Office, Industrial, Special Purpose property located at 5205 Old Buncombe Road, Greenville, SC 29609 for lease - image #1
$11/SF/YR
5205 Old Buncombe Road A1
FLEX SPACE FOR LEASE – 6,000± SF • GREENVILLE, SC

5205 Old Buncombe Road Greenville, SC 29609

Pictures of Office property located at 1025 Orleans, Charleston, SC 29407 for lease - image #1
$30/SF/YR
1025 Orleans
Office • Single tenant • 1,000 SqFt

1025 Orleans Charleston, SC 29407

Pictures of Retail, Office property located at 1320 44th Avenue North, Myrtle Beach, SC 29577 for lease - image #1
$27/SF/YR
OLA PLAZA

1320 44th Avenue North Myrtle Beach, SC 29577

Pictures of Office property located at 656 Ellis Oak Avenue # 113, Charleston, SC 29412 for lease - image #1
$118/SF/YR
656 Ellis Oak Avenue # 113
Office • Single tenant • 137 SqFt

656 Ellis Oak Avenue # 113 Charleston, SC 29412

Pictures of Retail, Office, Industrial property located at 120 S Main St, Lancaster, SC 29720 for lease - image #1
$4.87/SF/YR
120 S Main Showroom Warehouse
Retail • Single tenant • 12,320 SqFt

120 S Main St Lancaster, SC 29720

Pictures of Office property located at 127 Halton Village Cir, Greenville, SC 29615 for lease - image #1
$30 - $35/SF/YR
127 Halton Village Cir
Office • 4 spaces available • 2,500 SqFt - 10,000 SqFt

127 Halton Village Cir Greenville, SC 29615

INTELLIGENCE
Instantly evaluate properties and markets with confidence.
Analyze data, market trends, sales comps, demographics, and more.
Learn More
Pictures of Office property located at 1 Wellness Blvd, Irmo, SC 29063 for lease - image #1
$30/SF/YR
1 Wellness Boulevard
±2,941 SF Available in Class A Medical Building • Irmo, SC

1 Wellness Blvd Irmo, SC 29063

Pictures of Office property located at 100 Coastal Drive Suite 350, Charleston, SC 29492 for lease - image #1
$38.50 - $40/SF/YR
100 Coastal Drive Suite 350
Office • Single tenant • 4,000 SqFt - 18,099 SqFt

100 Coastal Drive Suite 350 Charleston, SC 29492

See New Listings First!
Save your filters and get alerts when new properties hit the market.
Save My Search
Pictures of Retail, Office property located at 5409 US-76, Pendleton, SC 29670 for lease - image #1
virtual tour
Undisclosed Rate
Prime Location on Hwy 76 near I-85, Suite B
Retail • Single tenant • 1,850 SqFt

5409 US-76 Pendleton, SC 29670

Pictures of Retail, Office property located at 5409 US-76, Pendleton, SC 29670 for lease - image #1
Undisclosed Rate
Prime Space for Rent off I-85 between Anderson & Clemson, SC
Retail • Single tenant • 1,850 SqFt

5409 US-76 Pendleton, SC 29670

Pictures of Retail, Office property located at 2821 Millwood Ave, Columbia, SC 29205 for lease - image #1
$18/SF/YR
2821 Millwood Ave
Retail

2821 Millwood Ave Columbia, SC 29205

Pictures of Office property located at 1830 Sumter St, Columbia, SC 29201 for lease - image #1
$17.50/SF/YR
1830 Sumter St
Office • Single tenant

1830 Sumter St Columbia, SC 29201

Pictures of Office property located at 1300 12th St, Cayce, SC 29033 for lease - image #1
$19.75/SF/YR
Brookland Place
Office • Single tenant

1300 12th St Cayce, SC 29033

Pictures of Office property located at 1514 & 1518 Pickens St, Columbia, SC 29201 for lease - image #1
$15.50/SF/YR
1514 & 1518 Pickens St
Office • 2,640 SqFt - 5,280 SqFt

1514 & 1518 Pickens St Columbia, SC 29201

Pictures of Office property located at 4 Carriage Lane # 308, Charleston, SC 29407 for lease - image #1
$24/SF/YR
4 Carriage Lane # 308
Office • Single tenant • 719 SqFt

4 Carriage Lane # 308 Charleston, SC 29407

Pictures of Office property located at 6613 N Kings Hwy, Myrtle Beach, SC 29572 for lease - image #1
$12/SF/YR
Dunes Plaza, Unit A, 2nd Floor
Office • Single tenant • 2,100 SqFt

6613 N Kings Hwy Myrtle Beach, SC 29572

Pictures of Retail, Office property located at 5224 Sunset Blvd, Lexington, SC 29072 for lease - image #1
Undisclosed Rate
Lexington Pavilion
Retail • Single tenant • 4,354 SqFt

5224 Sunset Blvd Lexington, SC 29072

Pictures of Office property located at 3250 Harden Street Extension, Columbia, SC 29203 for lease - image #1
$18/SF/YR
3250 Harden Street Ext, Suite 200
Office • Single tenant • 1,950 SqFt

3250 Harden Street Extension Columbia, SC 29203

Pictures of Office property located at 9 Rue Du Bois, Beaufort, SC 29907 for lease - image #1
$80/SF/YR
9A Rue Du Bois, Suite 2
Office • Single tenant • 90 SqFt

9 Rue Du Bois Beaufort, SC 29907

Pictures of Office property located at 3020 Devine Street, Columbia, SC 29205-1896 for lease - image #1
$25/SF/YR
3020 Devine Street
Office • 2 spaces available • 3,640 SqFt

3020 Devine Street Columbia, SC 29205-1896

Pictures of Retail, Office, Restaurant property located at Celanese Rd, Rock Hill, SC 29732 for lease - image #1
video
$40 - $45/SF/YR
Celanese North
Retail • 4 spaces available • 7,545 SqFt - 47,916 SqFt

Celanese Rd Rock Hill, SC 29732

Pictures of Office property located at 27B Kemmerlin Ln, Beaufort, SC 29907 for lease - image #1
$24.67/SF/YR
27B Kemmerlin Lane
Office • Single tenant • 1,500 SqFt

27B Kemmerlin Ln Beaufort, SC 29907

Pictures of Office property located at 3302 New Easley Hwy, Greenville, SC 29611 for lease - image #1
Undisclosed Rate
3302 New Easley Hwy (Hwy 123), Greenville, SC 29611
Office • Single tenant • 2,100 SqFt

3302 New Easley Hwy Greenville, SC 29611

Pictures of Retail, Office property located at 3583 US-17 BUS, Murrells Inlet, SC 29576 for lease - image #1
Undisclosed Rate
3583 U.S. 17 Business
Retail • Single tenant • 4,560 SqFt

3583 US-17 BUS Murrells Inlet, SC 29576

Pictures of Office property located at 477 Haywood Rd, Greenville, SC 29607 for lease - image #1
Undisclosed Rate
Regency Square Executive Office Center
Office • 1 space available • 110 SqFt

477 Haywood Rd Greenville, SC 29607

Pictures of Office property located at 906 Montague Ave, Greenwood, SC 29649 for lease - image #1
$2.62/SF/MO
Montague Single Office Space
Office • Single tenant • 191 SqFt

906 Montague Ave Greenwood, SC 29649

Pictures of Office property located at 2000 Sam Rittenberg Blvd, Charleston, SC 29407 for lease - image #1
$26.50/SF/YR
Harrell Square
Office • 1 space available • 4,064 SqFt

2000 Sam Rittenberg Blvd Charleston, SC 29407

Pictures of Office property located at 125 Dillon Dr, Spartanburg, SC 29307 for lease - image #1
Undisclosed Rate
125 Dillon Drive
Office • Single tenant • 10,000 SqFt

125 Dillon Dr Spartanburg, SC 29307

Pictures of Office property located at 4921 Centre Pointe Drive # 201 ##201, North Charleston, SC 29418 for lease - image #1
$22/SF/YR
4921 Centre Pointe Drive # 201 ##201
Office • Single tenant • 545 SqFt - 7,431 SqFt

4921 Centre Pointe Drive # 201 ##201 North Charleston, SC 29418

Pictures of Office property located at 215 E Bay St. # 401, Charleston, SC 29401 for lease - image #1
$23/SF/YR
The Maritime Building
Office • Single tenant • 1,785 SqFt

215 E Bay St. # 401 Charleston, SC 29401

Pictures of Office property located at 130 Spillman Ct, Travelers Rest, SC 29690 for lease - image #1
Undisclosed Rate
130 Spillman Ct
Office • 1 space available • 1,631 SqFt

130 Spillman Ct Travelers Rest, SC 29690

Pictures of Retail, Office property located at 147 Welborn St, Greenville, SC 29601 for lease - image #1
Undisclosed Rate
The Commons
Retail • 4 spaces available • 1,003 SqFt - 1,713 SqFt

147 Welborn St Greenville, SC 29601

Pictures of Office property located at 14361 Ocean Highway Unit C (2nd Floor), Pawleys Island, SC 29585 for lease - image #1
$1.39/SF/MO
Pawleys Island 2nd Floor Office Space
Office • Single tenant • 3,600 SqFt

14361 Ocean Highway Unit C (2nd Floor) Pawleys Island, SC 29585

Pictures of Office property located at 1009 Grove Rd, Greenville, SC 29605 for lease - image #1
$12.20/SF/YR
1009 Grove Rd.| Bldg. C
Office • Single tenant • 12,000 SqFt

1009 Grove Rd Greenville, SC 29605

Pictures of Office property located at 1244 E Butler Rd, Greenville, SC 29607 for lease - image #1
$12/SF/MO
Office Space Brick House Single Level plus 2 acres
Office • Single tenant • 2,296 SqFt

1244 E Butler Rd Greenville, SC 29607

Pictures of Office property located at 534 River Crossing Dr, Fort Mill, SC 29715 for lease - image #1
Undisclosed Rate
534 River Crossing Dr
Office • Single tenant • 1,150 SqFt

534 River Crossing Dr Fort Mill, SC 29715

Pictures of Retail, Office property located at 600 Laurens Rd, Greenville, SC 29607 for lease - image #1
Undisclosed Rate
600 Laurens Road B, D & E
Retail • 1,100 SqFt - 5,700 SqFt

600 Laurens Rd Greenville, SC 29607

Pictures of Office property located at 14 Monckton Blvd, Columbia, SC 29206 for lease - image #1
$20/SF/YR
14 Monckton Boulevard (second floor)
Office • 1 space available • 1,500 SqFt - 3,000 SqFt

14 Monckton Blvd Columbia, SC 29206

Pictures of Retail, Office property located at 2903 N Kings Hwy, Myrtle Beach, SC 29577 for lease - image #1
$16/SF/YR
29th Avenue Retail Center
Retail • Single tenant

2903 N Kings Hwy Myrtle Beach, SC 29577

Pictures of Retail, Office, Special Purpose property located at 1513 Heritage Ln, Florence, SC 29505 for lease - image #1
$17/SF/MO
1513 Heritage lane
Retail • Single tenant • 1,684 SqFt

1513 Heritage Ln Florence, SC 29505

Pictures of Retail, Office property located at 718 Front St, Georgetown, SC 29440 for lease - image #1
$30/SF/YR
Historic Front Street Retail/Office
Retail • Single tenant • 1,520 SqFt

718 Front St Georgetown, SC 29440

Pictures of Retail, Office property located at 114 E Curtis St, Simpsonville, SC 29681 for lease - image #1
$35/SF/YR
Burdette Central - Phase 2
Retail + Office • 1,381 - 7,000 sq. ft.

114 E Curtis St Simpsonville, SC 29681

Pictures of Retail, Office property located at 929 Gervais St, Columbia, SC 29201 for lease - image #1
$32/SF/YR
929 Gervais Street
±1,710 SF Retail/Office Space in the Heart of the Vista • Downtown Columbia

929 Gervais St Columbia, SC 29201

Pictures of Office property located at 1674 Cranium Drive, Rock Hill, SC 29732 for lease - image #1
$19/SF/YR
Price Reduced – 1,919 SF | Ste 102 | 1674 Cranium Dr
Office • Single tenant • 1,919 SqFt

1674 Cranium Drive Rock Hill, SC 29732

Pictures of Retail, Office property located at 1514 Brentwood Dr, Columbia, SC 29206 for lease - image #1
$33/Acre/YR
Brentwood at Forest Drive
Brand New ±1,000 - 4,480 SF Mixed-Use Space Located in Desirable Forest Acres • Columbia, SC

1514 Brentwood Dr Columbia, SC 29206

Pictures of Office property located at 413 Vardry St, Greenville, SC 29601 for lease - image #1
$28.80/SF/YR
West End Professional Park
Office • Single tenant • 1,700 SqFt

413 Vardry St Greenville, SC 29601

Pictures of Retail, Office, Restaurant property located at 5 Moorlyn Ln, Greer, SC 29650 for lease - image #1
$33 - $36/SF/YR
Urban Space Greer
Retail Development

5 Moorlyn Ln Greer, SC 29650

Pictures of Office, Special Purpose property located at 105 Lancaster St SW, Aiken, SC 29801 for lease - image #1
virtual tour
$15/SF/YR
105 Lancaster Street, Aiken SC
Downtown Office Building - 2 story - Historical

105 Lancaster St SW Aiken, SC 29801

Pictures of Retail, Office, Special Purpose property located at 1537 Main St, Columbia, SC 29201 for lease - image #1
$15 - $18/SF/YR
Top Floor | 3,120 SF
Retail • Single tenant • 3,120 SqFt

1537 Main St Columbia, SC 29201

Pictures of Office property located at 530 Howell Rd, Greenville, SC 29615 for lease - image #1
$20 - $22/SF/YR
Howell Ridge
Office • 3 spaces available • 1,150 SqFt - 1,950 SqFt

530 Howell Rd Greenville, SC 29615

Pictures of Retail, Office property located at 201 Smythe St, Greenville, SC 29611 for lease - image #1
$20/SF/YR
201 Smythe Street
Adaptive reuse office/retail space in historic mill • Greenville, SC

201 Smythe St Greenville, SC 29611

Pictures of Retail, Office property located at 325 Taylor St, Columbia, SC 29201 for lease - image #1
$18/SF/YR
Sola Station
Retail • 8 spaces available • 1,168 SqFt - 3,335 SqFt

325 Taylor St Columbia, SC 29201

Pictures of Office property located at 1416 Laurel St, Columbia, SC 29201 for lease - image #1
$16/SF/YR
1416-1418 Laurel St.
Office • 1 space available • 750 SqFt

1416 Laurel St Columbia, SC 29201

Pictures of Retail, Office property located at 579 King Street, Charleston, SC 29403 for lease - image #1
$23/SF/YR
579 King Street
Retail • 1 space available • 2,000 SqFt

579 King Street Charleston, SC 29403

Pictures of Office property located at 107 W 6th N St, Summerville, SC 29483 for lease - image #1
$31/SF/YR
107 W 6th North Street, Suite 203
Office • 1 space available • 1,839 SqFt

107 W 6th N St Summerville, SC 29483

Pictures of Office, Retail property located at 1927 W Palmetto St, Florence, SC 29501 for lease - image #1
virtual tour
Undisclosed Rate
1927 W Palmetto St
Office • 1 space available • 2,000 SqFt

1927 W Palmetto St Florence, SC 29501

Pictures of Office property located at 40 Calhoun Street Suite 210 #Suite 210-South, Charleston, SC 29401 for lease - image #1
$38/SF/YR
Charleston Gateway Center
Charleston Gateway Office Space for lease

40 Calhoun Street Suite 210 #Suite 210-South Charleston, SC 29401

Pictures of Retail, Office property located at 5418 Rivers Ave, North Charleston, SC 29406 for lease - image #1
$22/SF/YR
Renovated Office / Retail Suite
Retail • Single tenant • 22 SqFt

5418 Rivers Ave North Charleston, SC 29406

Pictures of Office property located at 263 King St, Charleston, SC 29401 for lease - image #1
$24/SF/YR
Built-out King Street Office Space
Office • Single tenant • 2,200 - 4,400 SqFt

263 King St Charleston, SC 29401

Pictures of Office, Industrial property located at 7275 Cross County Rd, North Charleston, SC 29418 for lease - image #1
$12/SF/YR
7275 Cross County Road Multiple Suites Available
4,880 sq ft warehouse Cross County Rd North Charleston

7275 Cross County Rd North Charleston, SC 29418

Nearby Office Spaces

Show Less

Show Less
For assistance, reach out to our support team at [email protected] or call 888.273.0423 . For press inquiries, contact [email protected]
Equal Housing Opportunity
5510 Lincoln Blvd #400, Los Angeles, CA 90094Commercial Real Estate Exchange, Inc.Crexi Technologies, LLCCXTechnology, LLC
© 2026 Commercial Real Estate Exchange, Inc. All Rights Reserved. DRE #02086591