www.crexi.com - The Commercial Real Estate Exchange
For Lease
Enter a location or keyword
For Lease
Special Purpose 

South Carolina Special Purpose Spaces for Lease

Export Results
393 spaces
Recommended 
Pictures of Office, Special Purpose property located at 1413 Calhoun Street, Columbia, SC 29201 for lease - image #1
$36.42/SF/YR
1413 Calhoun Street
1st Floor Single Office Space

1413 Calhoun Street Columbia, SC 29201

Pictures of Special Purpose property located at 4200 Piggly Wiggly Drive, North Charleston, SC 29405 for lease - image #1
$5,500/Acre/YR
4200 Piggly Wiggly Drive
Special Purpose • Single tenant • 3 acre

4200 Piggly Wiggly Drive North Charleston, SC 29405

Pictures of Special Purpose property located at 4033 W Montague Avenue, North Charleston, SC 29418 for lease - image #1
$10 - $15/SF/YR
4033 W Montague Avenue
Special Purpose • Single tenant • 6,175 SqFt

4033 W Montague Avenue North Charleston, SC 29418

Pictures of Special Purpose property located at 4500 East Leeds Avenue, North Charleston, SC 29405 for lease - image #1
$16 - $20/SF/YR
4500 East Leeds Avenue
Special Purpose • Single tenant • 7,667 SqFt - 26,163 SqFt

4500 East Leeds Avenue North Charleston, SC 29405

Pictures of Special Purpose property located at 289 Huger Street, Charleston, SC 29403 for lease - image #1
$40/SF/YR
289 Huger Street
Special Purpose • Single tenant • 13,342 SqFt

289 Huger Street Charleston, SC 29403

Pictures of Special Purpose property located at 1420 Red Bank Rd, Goose Creek, SC 29445 for lease - image #1
$24/SF/MO
1420 Beauty Salon
Special Purpose • Single tenant • 2,500 SqFt

1420 Red Bank Rd Goose Creek, SC 29445

INTELLIGENCE
Instantly evaluate properties and markets with confidence.
Analyze data, market trends, sales comps, demographics, and more.
Learn More
Pictures of Special Purpose property located at 780 N Church Street, Spartanburg, SC 29303 for lease - image #1
$16/SF/YR
780 N Church Street
Turn-key automotive shop for sale or lease

780 N Church Street Spartanburg, SC 29303

Pictures of Office, Special Purpose property located at 180 Spring St, Charleston, SC 29403 for lease - image #1
virtual tour
$1,250/SF/MO
180 Spring Street
Office • 1 space available • 400 SqFt - 550 SqFt

180 Spring St Charleston, SC 29403

See New Listings First!
Save your filters and get alerts when new properties hit the market.
Save My Search
Pictures of Retail, Office, Special Purpose property located at US-76, Anderson, SC 29621 for lease - image #1
Undisclosed Rate
00 Highway 76 Lot 6
Retail • Single tenant • 9,800 SqFt

US-76 Anderson, SC 29621

Pictures of Industrial, Special Purpose property located at 26-A Williams Ln, Hardeeville, SC 29927, Hardeeville, SC 29927 for lease - image #1
Undisclosed Rate
1,200 SF Insulated Multipurpose Flex Space
Industrial • Single tenant • 1,200 SqFt

26-A Williams Ln, Hardeeville, SC 29927 Hardeeville, SC 29927

Pictures of Office, Special Purpose property located at 12019 Ocean Hwy, Pawleys Island, SC 29585 for lease - image #1
$3,250/SF/MO
Pawley's Place
Office • 1,800 SqFt

12019 Ocean Hwy Pawleys Island, SC 29585

Pictures of Office, Special Purpose property located at 1323 Celebration Blvd, Florence, SC 29501 for lease - image #1
virtual tour
$20 - $25/SF/YR
1323 Celebration Blvd
Office • 1 space available • 12,000 SqFt - 37,000 SqFt

1323 Celebration Blvd Florence, SC 29501

Pictures of Special Purpose property located at 228 Silver Bluff Road, Aiken, SC 29803 for lease - image #1
$1.61/SF/MO
228 Silver Bluff Road
Special Purpose • Single tenant • 1,246 SqFt

228 Silver Bluff Road Aiken, SC 29803

Pictures of Special Purpose property located at 209 Silver Bluff Road, Aiken, SC 29803 for lease - image #1
$0.86/SF/MO
209 Silver Bluff Road
Special Purpose • Single tenant • 1,450 SqFt

209 Silver Bluff Road Aiken, SC 29803

Pictures of Special Purpose property located at 220 Georgia Avenue, North Augusta, SC 29841 for lease - image #1
$2.43/SF/MO
220 Georgia Avenue
Special Purpose • Single tenant • 1,440 SqFt

220 Georgia Avenue North Augusta, SC 29841

Pictures of Retail, Special Purpose property located at 951 Old Cherokee Rd, Lexington, SC 29072 for lease - image #1
virtual tour
$24 - $34/SF/YR
1000 SQFT for Rent @ Established Gym for $2000 Per Month
Rent Space in Operating Gym!

951 Old Cherokee Rd Lexington, SC 29072

Pictures of Land, Special Purpose, Retail property located at 8500 Two Notch Rd, Columbia, SC 29223 for lease - image #1
$85,714/Acre/YR
Columbia SC Ground Lease
Ground Lease • $9k Per Month • 1.26 acre

8500 Two Notch Rd Columbia, SC 29223

Pictures of Retail, Industrial, Special Purpose property located at 4955 Socastee Blvd, Myrtle Beach, SC 29588 for lease - image #1
$4,500/SF/MO
Warehouse
Retail • Single tenant • 4,500 SqFt

4955 Socastee Blvd Myrtle Beach, SC 29588

Pictures of Office, Special Purpose property located at 1051 Johnnie Dodds Blvd, Mt Pleasant, SC 29464 for lease - image #1
virtual tour
$2.83/SF/MO
Juliana Clinics and Studios
Office • 1 space available • 1,654 SqFt

1051 Johnnie Dodds Blvd Mt Pleasant, SC 29464

Pictures of Retail, Office, Special Purpose property located at 1318 Bush River Rd, Columbia, SC 29210 for lease - image #1
virtual tour
$13/SF/YR
Church, Restaurant, Vape, Hochah
Retail • 1 space available • 0 SqFt - 4,800 SqFt

1318 Bush River Rd Columbia, SC 29210

Pictures of Retail, Office, Special Purpose property located at 171 Spring St, Charleston, SC 29403 for lease - image #1
$94/SF/MO
171 Spring Street
Prime Commercial Space Downtown Charleston

171 Spring St Charleston, SC 29403

Pictures of Retail, Office, Special Purpose property located at 6251 Highway 162 #E, Hollywood, SC 29449 for lease - image #1
$20.40/SF/YR
6251 Highway 162 #E
Retail • Single tenant • 1,200 SqFt

6251 Highway 162 #E Hollywood, SC 29449

Pictures of Office, Special Purpose property located at 401 Western Lane, Irmo, SC 29063 for lease - image #1
video
$17.16/SF/YR
401 Western Lane Suite 8B
1500 sf office with quick I26 access in Irmo, SC

401 Western Lane Irmo, SC 29063

Pictures of Office, Industrial, Special Purpose property located at 150 Centrum Dr, Irmo, SC 29063 for lease - image #1
$16/SF/YR
1900-7000 SF Industrial Building available for lease
5,100 Still Available - Industrial Building -Pre-Leasing

150 Centrum Dr Irmo, SC 29063

Pictures of Office, Special Purpose property located at 1016 Rah Rah Rd, Irmo, SC 29063 for lease - image #1
$12/Acre/YR
5500+/- Multi-Use Facility
±5,500 SF Flex Building on ±1.5 acres

1016 Rah Rah Rd Irmo, SC 29063

Pictures of Retail, Office, Special Purpose property located at 1215 Boiling Springs Road, Spartanburg, SC 29303 for lease - image #1
$10/SF/YR
1215 Boiling Springs Road
Office/Retail Space on Boiling Springs Rd

1215 Boiling Springs Road Spartanburg, SC 29303

Pictures of Special Purpose property located at 1184 Bees Ferry Road # 102 #A-102, Johns Island, SC 29455 for lease - image #1
$39/SF/YR
1184 Bees Ferry Road # 102 #A-102
Special Purpose • Single tenant • 1,459 SqFt

1184 Bees Ferry Road # 102 #A-102 Johns Island, SC 29455

Pictures of Special Purpose property located at 1180 Bees Ferry Road # 104 #B-104, Johns Island, SC 29455 for lease - image #1
$39/SF/YR
1180 Bees Ferry Road # 104 #B-104
Special Purpose • Single tenant • 1,654 SqFt - 3,116 SqFt

1180 Bees Ferry Road # 104 #B-104 Johns Island, SC 29455

Pictures of Special Purpose property located at 1033 Wappoo Road # G #F-G, Charleston, SC 29407 for lease - image #1
$18/SF/YR
1033 Wappoo Road # G #F-G
Special Purpose • Single tenant • 9,409 SqFt

1033 Wappoo Road # G #F-G Charleston, SC 29407

Pictures of Special Purpose property located at Us-52, Goose Creek, SC 29445 for lease - image #1
$35/SF/YR
Us-52
Special Purpose • Single tenant • 1,532 SqFt - 8,900 SqFt

Us-52 Goose Creek, SC 29445

Pictures of Restaurant, Office, Special Purpose property located at 504 Main St, North Myrtle Beach, SC 29582 for lease - image #1
Undisclosed Rate
5,000+/- SF Building on Main Street (Duplex)
Retail • Subdividable • 2,500 to 5,000 SqFt

504 Main St North Myrtle Beach, SC 29582

Pictures of Special Purpose property located at 2843 W Palmetto Street Suite C, Florence, SC 29501 for lease - image #1
Undisclosed Rate
2843 W Palmetto Street Suite C
Special Purpose • Single tenant • 1,100 SqFt

2843 W Palmetto Street Suite C Florence, SC 29501

Pictures of Retail, Special Purpose property located at 115 Pelham Rd, Greenville, SC 29615 for lease - image #1
Undisclosed Rate
115 Pelham Lower Level
Flex Space for Lease • ±7,250 sf

115 Pelham Rd Greenville, SC 29615

Pictures of Industrial, Special Purpose property located at 1334 Simmons Rd, Yemassee, SC 29945 for lease - image #1
$4.70/SF/YR
1334 Simmons Rd, Yemassee, SC
Industrial • Single tenant • 24,225 SqFt

1334 Simmons Rd Yemassee, SC 29945

Pictures of Retail, Office, Special Purpose property located at Fountain Inn, SC, Fountain Inn, SC 29644 for lease - image #1
$25/SF/YR
Village at Woodside
Retail space for lease in new mixed-use development

Fountain Inn, SC Fountain Inn, SC 29644

Pictures of Special Purpose property located at 8710 Dorchester Rd, North Charleston, SC 29420 for lease - image #1
Undisclosed Rate
8710 Dorchester Rd
Land • 1.93 Acres

8710 Dorchester Rd North Charleston, SC 29420

Pictures of Special Purpose property located at 1637 Savannah Highway # 201, Charleston, SC 29407 for lease - image #1
$24/SF/YR
1637 Savannah Highway # 201
Special Purpose • Single tenant • 1,100 SqFt

1637 Savannah Highway # 201 Charleston, SC 29407

Pictures of Special Purpose property located at 1065 Saint James Avenue, Goose Creek, SC 29486 for lease - image #1
$35/SF/YR
1065 Saint James Avenue
Special Purpose • Single tenant • 1,200 SqFt - 11,040 SqFt

1065 Saint James Avenue Goose Creek, SC 29486

Pictures of Special Purpose property located at 547 Long Point Road, Mount Pleasant, SC 29464 for lease - image #1
$20/SF/YR
547 Long Point Road
Special Purpose • Single tenant • 17,266 SqFt

547 Long Point Road Mount Pleasant, SC 29464

Pictures of Industrial, Special Purpose property located at 1949 Dulsey Road, Charleston, SC 29407 for lease - image #1
$16.02/SF/YR
1949 Dulsey Road, Unit 201

1949 Dulsey Road Charleston, SC 29407

Pictures of Special Purpose property located at 1450 E Northside Avenue, Marion, SC 29571 for lease - image #1
Undisclosed Rate
1450 E Northside Avenue
Special Purpose • 1 space available • 2,000 SqFt

1450 E Northside Avenue Marion, SC 29571

Pictures of Special Purpose property located at 401 2nd Loop Rd, Florence, SC 29505 for lease - image #1
$14/SF/YR
For Lease 2nd Loop Rd. 1200 Sq. Ft.
Special Purpose • Single tenant • 1,200 SqFt

401 2nd Loop Rd Florence, SC 29505

Pictures of Retail, Office, Special Purpose property located at 882 E Main St, Spartanburg, SC 29302 for lease - image #1
Undisclosed Rate
882 E Main St - DOWNTOWN SPARTANBURG
Retail • Single tenant • 1,820 SqFt

882 E Main St Spartanburg, SC 29302

Pictures of Retail, Office, Special Purpose property located at 721 SE Main St, Simpsonville, SC 29681 for lease - image #1
Undisclosed Rate
Simpsonville Retail Development
Retail • 1 space available • 4,375 SqFt

721 SE Main St Simpsonville, SC 29681

Pictures of Special Purpose property located at 10 Target Road, Hilton Head Island, SC 29928 for lease - image #1
$1/SF/YR
10 Target Road
Special Purpose • Single tenant • 1,000 SqFt - 22,082 SqFt

10 Target Road Hilton Head Island, SC 29928

Pictures of Industrial, Special Purpose property located at 385 French Collins Road # C #Building C, Conway, SC 29526 for lease - image #1
$8/SF/YR
385 French Collins Road #C
Industrial, Office & IOS Space for Lease

385 French Collins Road # C #Building C Conway, SC 29526

Pictures of Special Purpose property located at 7587 Sandlapper Parkway # 100, North Charleston, SC 29420 for lease - image #1
$10.50/SF/YR
7587 Sandlapper Parkway # 100
Special Purpose • Single tenant • 10,032 SqFt

7587 Sandlapper Parkway # 100 North Charleston, SC 29420

Pictures of Special Purpose property located at 1133 St James Avenue #Suite 101/102, Summerville, SC 29486 for lease - image #1
$33/SF/YR
1133 St James Avenue #Suite 101/102
Special Purpose • Single tenant • 2,998 SqFt

1133 St James Avenue #Suite 101/102 Summerville, SC 29486

Pictures of Special Purpose property located at 1135 St James Avenue Suite 104, Summerville, SC 29486 for lease - image #1
$32/SF/YR
1135 St James Avenue Suite 104
Special Purpose • Single tenant • 1,213 SqFt - 4,850 SqFt

1135 St James Avenue Suite 104 Summerville, SC 29486

Pictures of Special Purpose property located at 1310 Meeting Street Suite B1, Charleston, SC 29405 for lease - image #1
$28/SF/YR
1310 Meeting Street Suite B1
Special Purpose • Single tenant • 2,178 SqFt - 7,905 SqFt

1310 Meeting Street Suite B1 Charleston, SC 29405

Pictures of Special Purpose property located at 6347 Savannah Highway, Ravenel, SC 29470 for lease - image #1
$15/SF/YR
6347 Savannah Highway
Special Purpose • Single tenant • 8,424 SqFt

6347 Savannah Highway Ravenel, SC 29470

Pictures of Special Purpose property located at 2225 Ashley Crossing Drive # 202, Charleston, SC 29414 for lease - image #1
$25/SF/YR
2225 Ashley Crossing Drive # 202
Special Purpose • Single tenant • 700 SqFt

2225 Ashley Crossing Drive # 202 Charleston, SC 29414

Pictures of Special Purpose property located at 1233 Ben Sawyer #500/600/700, Mount Pleasant, SC 29464 for lease - image #1
$60/SF/YR
1233 Ben Sawyer #500/600/700
Special Purpose • Single tenant • 461 SqFt

1233 Ben Sawyer #500/600/700 Mount Pleasant, SC 29464

Pictures of Office, Industrial, Special Purpose property located at 280 National Avenue, Spartanburg, SC 29303 for lease - image #1
$5.25/SF/YR
±62,000 SF Office/Industrial Space with Heavy Power Off I-26
±62,000 SF Office/Industrial Space with Heavy Power Off I-26

280 National Avenue Spartanburg, SC 29303

Pictures of Industrial, Land, Special Purpose property located at 00 National Avenue, Spartanburg, SC 29303 for lease - image #1
$3,000/Acre/YR
00 National Avenue
±8 Acre Industrial Outdoor Storage (IOS) Space Off I-26

00 National Avenue Spartanburg, SC 29303

Pictures of Retail, Special Purpose property located at 9538 Augusta Road, Pelzer, SC 29669 for lease - image #1
$7.25/SF/YR
9538 Augusta Road
Freestanding Flex/Warehouse • ±9,375 SF • New HVAC • Drive-In Capability

9538 Augusta Road Pelzer, SC 29669

Pictures of Special Purpose property located at 451 Comet Creek Lane, Goose Creek, SC 29445 for lease - image #1
$19.50/SF/YR
451 Comet Creek Lane
Special Purpose • 5 spaces available • 660 SqFt - 4,556 SqFt

451 Comet Creek Lane Goose Creek, SC 29445

Pictures of Industrial, Land, Special Purpose property located at 1095 Simuel Rd, Spartanburg, SC 29301 for lease - image #1
$12 - $14.75/SF/YR
1095 Simuel Road
Build to Suit Opportunity for Lease - 11,435 SqFt - 52,000 SqFt

1095 Simuel Rd Spartanburg, SC 29301

Pictures of Office, Industrial, Special Purpose property located at 6548 Ward Ave, North Charleston, SC 29406 for lease - image #1
virtual tour
$19.50/SF/YR
Flex-Unit - Charleston Mixed-Use Warehouse
Office • 2 spaces available • 2,210 SqFt - 2,860 SqFt

6548 Ward Ave North Charleston, SC 29406

Pictures of Industrial, Land, Special Purpose property located at E Cherokee St, Blacksburg, SC 29702 for lease - image #1
Undisclosed Rate
E Cherokee St & Hwy 5
Industrial • 1 space available • 100,000 SqFt - 500,000 SqFt

E Cherokee St Blacksburg, SC 29702

Results per page:
Previous 1 .. 2 .. 3 4 .. 5 Next
  1. Crexi
  2. For Lease
  3. SC
  4. Special Purpose

Nearby Special Purpose Spaces

Show Less

Show Less
Trustpilot
For assistance, reach out to our support team at [email protected] or call 888.273.0423 . For press inquiries, contact [email protected]
Equal Housing Opportunity
5510 Lincoln Blvd #400, Los Angeles, CA 90094Commercial Real Estate Exchange, Inc.Crexi Technologies, LLCCXTechnology, LLC
© 2026 Commercial Real Estate Exchange, Inc. All Rights Reserved. DRE #02086591
Do not sell or share my personal information
Tax NoticesLicensingTerms of ServicePrivacy PolicySite Map